Low LAL (Lysosomal Acid Lipase) Expression by Smooth Muscle Cells Relative to Macrophages as a Mechanism for Arterial Foam Cell Formation

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e354-e368. doi: 10.1161/ATVBAHA.120.316063. Epub 2021 Apr 1.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cholesterol; foam cells; macrophages; myocytes; smooth muscle.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / enzymology
  • Aorta / pathology
  • Atherosclerosis / enzymology*
  • Atherosclerosis / genetics
  • Atherosclerosis / pathology
  • Cholesterol / metabolism*
  • Disease Models, Animal
  • Foam Cells / enzymology*
  • Foam Cells / pathology
  • Humans
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout, ApoE
  • Muscle, Smooth, Vascular / enzymology*
  • Muscle, Smooth, Vascular / pathology
  • Myocytes, Smooth Muscle / enzymology*
  • Myocytes, Smooth Muscle / pathology
  • RAW 264.7 Cells
  • Sterol Esterase / metabolism*

Substances

  • Cholesterol
  • LIPA protein, human
  • Sterol Esterase
  • lysosomal acid lipase, mouse