Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1694-1709. doi: 10.1161/ATVBAHA.120.315546. Epub 2021 Mar 25.

Abstract

[Figure: see text].

Keywords: angiotensin II; calpain; cytoskeletal protein; filamin A; tamoxifen.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Angiotensin II
  • Animals
  • Aorta, Abdominal / enzymology*
  • Aorta, Abdominal / pathology
  • Aortic Aneurysm, Abdominal / chemically induced
  • Aortic Aneurysm, Abdominal / enzymology
  • Aortic Aneurysm, Abdominal / genetics
  • Aortic Aneurysm, Abdominal / prevention & control*
  • Aortic Rupture / chemically induced
  • Aortic Rupture / enzymology
  • Aortic Rupture / genetics
  • Aortic Rupture / prevention & control*
  • Calpain / deficiency*
  • Calpain / genetics
  • Calpain / metabolism
  • Cells, Cultured
  • Cytoskeleton / enzymology
  • Cytoskeleton / pathology
  • Dilatation, Pathologic
  • Disease Models, Animal
  • Extracellular Matrix / enzymology
  • Extracellular Matrix / pathology
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Rats
  • Receptors, LDL / deficiency
  • Receptors, LDL / genetics
  • Vascular Remodeling*

Substances

  • Receptors, LDL
  • Angiotensin II
  • Calpain
  • CAPN2 protein, human
  • Capn2 protein, mouse
  • Capn2 protein, rat