Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e299-e313. doi: 10.1161/ATVBAHA.121.316066. Epub 2021 Mar 25.

Alan Chait^{1

2}, Shari Wang^{1

2}, Leela Goodspeed^{1

2}, Diego Gomes^{1

2}, Katherine E Turk^{1

2}, Tomasz Wietecha^{2

3}, Jingjing Tang^{1

2}, Carl Storey^{1

2}, Kevin D O'Brien^{2

3}, Katya B Rubinow^{1

2}, Chongren Tang^{1

2}, Tomas Vaisar^{1

2}, Sina A Gharib⁴, Aldons J Lusis⁵, Laura J Den Hartigh^{1

2}

¹ Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition (A.C., S.W., L.G., D.G., K.E.T., J.T., C.S., K.B.R., C.T., T.V., L.J.D.H.), University of Washington, Seattle.
² Diabetes Institute (A.C., S.W., L.G., D.G., K.E.T., T.W., J.T., C.S., K.D.O., K.B.R., C.T., T.V., L.J.D.H.), University of Washington, Seattle.
³ Department of Medicine, Division of Cardiology (T.W., K.D.O.), University of Washington, Seattle.
⁴ Division of Pulmonary, Critical Care and Sleep Medicine, Computational Medicine Core, Department of Medicine, Center for Lung Biology (S.A.G.), University of Washington, Seattle.
⁵ Department of Human Genetics, University of California, Los Angeles (A.J.L.).

Abstract

[Figure: see text].

Keywords: cholesterol; cholesterol efflux; hyperlipidemia; macrophages; sex steroids; triggering receptor expressed on myeloid cells 2.