Heme Oxygenase-1 in Macrophages Impairs the Perfusion Recovery After Hindlimb Ischemia by Suppressing Autolysosome-Dependent Degradation of NLRP3

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1710-1723. doi: 10.1161/ATVBAHA.121.315805. Epub 2021 Mar 25.

Abstract

[Figure: see text].

Keywords: heme oxygenase-1; hindlimb ischemia; inflammasome; macrophage; mice; perfusion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Databases, Genetic
  • Disease Models, Animal
  • Heme Oxygenase-1 / genetics
  • Heme Oxygenase-1 / metabolism*
  • Hindlimb
  • Humans
  • Inflammasomes / genetics
  • Inflammasomes / metabolism*
  • Inflammation Mediators / metabolism
  • Ischemia / enzymology*
  • Ischemia / genetics
  • Ischemia / physiopathology
  • Lysosomes / enzymology*
  • Macrophages / enzymology*
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Skeletal / blood supply*
  • Muscle, Skeletal / enzymology*
  • Muscle, Skeletal / physiopathology
  • NLR Family, Pyrin Domain-Containing 3 Protein / genetics
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*
  • Neovascularization, Physiologic
  • Proteolysis
  • Recovery of Function
  • Regional Blood Flow

Substances

  • Inflammasomes
  • Inflammation Mediators
  • Membrane Proteins
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nlrp3 protein, mouse
  • Heme Oxygenase-1
  • Hmox1 protein, mouse