Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):e265-e279. doi: 10.1161/ATVBAHA.120.315837. Epub 2021 Mar 25.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT02561000.

Keywords: atherosclerosis; collagen; fibrillar collagens; monocytes; necrosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Coronary Syndrome / enzymology*
  • Acute Coronary Syndrome / pathology
  • Acute Coronary Syndrome / therapy
  • Animals
  • Aorta / enzymology*
  • Aorta / pathology
  • Atherosclerosis / enzymology
  • Atherosclerosis / genetics
  • Atherosclerosis / pathology
  • Atherosclerosis / prevention & control*
  • Cardiac Catheterization / adverse effects
  • Cell-Penetrating Peptides / therapeutic use
  • Cells, Cultured
  • Coronary Artery Disease / enzymology*
  • Coronary Artery Disease / pathology
  • Coronary Artery Disease / therapy
  • Disease Models, Animal
  • Female
  • Fibrillar Collagens / metabolism*
  • Fibrosis
  • Humans
  • Lipopeptides / therapeutic use
  • Male
  • Matrix Metalloproteinase 1 / deficiency*
  • Matrix Metalloproteinase 1 / genetics
  • Matrix Metalloproteinase 1 / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout, ApoE
  • Monocytes / drug effects
  • Monocytes / enzymology*
  • Monocytes / pathology
  • Percutaneous Coronary Intervention / adverse effects
  • Plaque, Atherosclerotic
  • Randomized Controlled Trials as Topic

Substances

  • Cell-Penetrating Peptides
  • Fibrillar Collagens
  • Lipopeptides
  • PZ-128 peptide
  • MMP1 protein, human
  • Matrix Metalloproteinase 1
  • Mmp1a protein, mouse

Associated data

  • ClinicalTrials.gov/NCT02561000