Assessing hemodynamic response to submaximal exercise in pulmonary arterial hypertension patients using an implantable hemodynamic monitor

J Heart Lung Transplant. 2021 Jun;40(6):430-434. doi: 10.1016/j.healun.2021.01.1964. Epub 2021 Feb 5.

Abstract

Pulmonary arterial hypertension (PAH) is a chronic, progressive disease that is incurable, even with effective therapy. Long-term outcome in PAH is best preserved by targeting hemodynamic improvements to reduce risk of subsequent right ventricular (RV) failure. Methods that can assess RV adaptation to stress have important implications to better understand an individual's physiology and may play a pivotal role in guiding therapy in PAH. In this novel pilot study, we evaluate the feasibility of monitoring hemodynamic response to 6-minute walk distance in patients with PAH using the CardioMEMS HF System.

Keywords: CardioMEMS; exercise, medical therapy; heart failure; hemodynamics; pulmonary hypertension; right-sided heart failure.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Disease Progression
  • Electrodes, Implanted*
  • Equipment Design
  • Female
  • Follow-Up Studies
  • Heart Failure / etiology*
  • Heart Failure / physiopathology
  • Heart Failure / prevention & control
  • Hemodynamics / physiology*
  • Humans
  • Male
  • Middle Aged
  • Monitoring, Physiologic / instrumentation*
  • Pilot Projects
  • Pulmonary Arterial Hypertension / complications
  • Pulmonary Arterial Hypertension / diagnosis
  • Pulmonary Arterial Hypertension / physiopathology*
  • Walking / physiology*