Basics of Coronary Thermodilution

JACC Cardiovasc Interv. 2021 Mar 22;14(6):595-605. doi: 10.1016/j.jcin.2020.12.037.

Abstract

Coronary microvascular dysfunction is a highly prevalent condition in both obstructive and nonobstructive coronary artery disease. Intracoronary thermodilution is a promising technique to investigate coronary microvascular (dys)function in vivo and to assess its most important metric: microvascular resistance. Here, the authors provide a practical review of bolus and continuous thermodilution for the measurement of coronary flow and microvascular resistance. The authors describe the basic principles of indicator-dilution theory and of coronary thermodilution and detail the practicalities of their application in the catheterization laboratory. Finally, the authors discuss contemporary clinical applications of coronary thermodilution-based microvascular assessment in humans and future perspectives.

Keywords: bolus coronary thermodilution; continuous coronary thermodilution; coronary microvascular dysfunction; indicator-dilution theory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Coronary Circulation*
  • Coronary Vessels / diagnostic imaging
  • Humans
  • Microcirculation
  • Thermodilution*
  • Treatment Outcome
  • Vascular Resistance