MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease

Circ Res. 2021 Apr 16;128(8):1173-1190. doi: 10.1161/CIRCRESAHA.120.318124. Epub 2021 Mar 11.

Abstract

[Figure: see text].

Keywords: endothelial cells; lncRNA; microRNAs; pulmonary arterial hypertension; vascular remodeling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epithelial-Mesenchymal Transition*
  • Heterogeneous-Nuclear Ribonucleoproteins / metabolism
  • Human Umbilical Vein Endothelial Cells / metabolism
  • Humans
  • Hypertension, Pulmonary / genetics
  • Hypertension, Pulmonary / metabolism*
  • Hypertension, Pulmonary / pathology
  • Mice
  • Polypyrimidine Tract-Binding Protein / metabolism
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism*
  • Transcriptome
  • Vascular Remodeling

Substances

  • Heterogeneous-Nuclear Ribonucleoproteins
  • PTBP1 protein, human
  • RNA, Long Noncoding
  • long non-coding RNA MIR503HG, human
  • Polypyrimidine Tract-Binding Protein