Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia

Circ Res. 2021 May 28;128(11):1679-1693. doi: 10.1161/CIRCRESAHA.120.317612. Epub 2021 Mar 3.

Stephanie A Worton^{1

2}, Harry A T Pritchard³, Susan L Greenwood¹, Mariam Alakrawi³, Alexander E P Heazell^{1

2}, Mark Wareing¹, Adam Greenstein^{2

3}, Jenny E Myers^{1

2}

¹ Maternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).
² Manchester University Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (S.A.W., A.E.P.H., A.G., J.E.M.).
³ Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (H.A.T.P., M.A., A.G.).

Abstract

[Figure: see text].

Keywords: hypertension; kynurenine; large-conductance calcium-activated potassium channels; pre-eclampsia; pregnancy; tryptophan.

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / antagonists & inhibitors
Adenylyl Cyclase Inhibitors / pharmacology
Adult
Calcium Channel Blockers / pharmacology
Endothelium, Vascular / drug effects
Female
Humans
Indoles / pharmacology
Kynurenine / pharmacology*
Muscle, Smooth, Vascular / cytology
Myometrium / blood supply
Omentum / blood supply
Peptides / pharmacology
Pre-Eclampsia / drug therapy*
Pre-Eclampsia / physiopathology
Pregnancy
Ryanodine Receptor Calcium Release Channel / drug effects
Vascular Resistance / drug effects*
Vascular Resistance / physiology
Vasoconstrictor Agents / antagonists & inhibitors
Vasodilation* / drug effects
Vasodilation* / physiology
Vasodilator Agents / pharmacology*