Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas

Circ Res. 2021 Apr 30;128(9):1279-1296. doi: 10.1161/CIRCRESAHA.120.318458. Epub 2021 Feb 25.

Peter Hanna^{1

2}, Michael J Dacey^{1

2}, Jaclyn Brennan³, Alison Moss⁴, Shaina Robbins⁴, Sirisha Achanta⁴, Natalia P Biscola⁵, Mohammed A Swid¹, Pradeep S Rajendran¹, Shumpei Mori¹, Joseph E Hadaya^{1

2}, Elizabeth H Smith⁶, Stanley G Peirce⁶, Jin Chen⁷, Leif A Havton^{8

9}, Zixi Jack Cheng⁷, Rajanikanth Vadigepalli⁴, James Schwaber⁴, Robert L Lux¹, Igor Efimov³, John D Tompkins¹, Donald B Hoover^{6

10}, Jeffrey L Ardell^{1

2}, Kalyanam Shivkumar^{1

2}

¹ Department of Medicine, Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (UCLA; P.H., M.J.D., M.A.S., P.S.R., S.M., J.E.H., R.L.L., J.D.T., J.L.A., K.S.).
² UCLA Molecular, Cellular and Integrative Physiology Program (P.H., M.J.D., J.E.H., J.L.A., K.S.).
³ Bioengineering, George Washington University, Washington, DC (J.B., I.E.).
⁴ Daniel Baugh Institute for Functional Genomics/Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA (A.M., S.R., S.A., R.V., J.S.).
⁵ Neurology (N.P.B.), Icahn School of Medicine at Mount Sinai, New York City, NY.
⁶ Biomedical Sciences (E.H.S., S.G.P., D.B.H.), James H. Quillen College of Medicine, East Tennessee State University.
⁷ Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando (J.C., Z.J.C.).
⁸ Neuroscience (L.A.H.), Icahn School of Medicine at Mount Sinai, New York City, NY.
⁹ VA RR&D National Center of Excellence for the Medical Consequences of Spinal and Cord Injury and Neurology Service, James J. Peters Veterans Administration Medical Center, Bronx, NY (L.A.H.).
¹⁰ Center of Excellence in Inflammation, Infectious Disease and Immunity (D.B.H.), James H. Quillen College of Medicine, East Tennessee State University.

Abstract

[Figure: see text].

Keywords: autonomic nervous system; electrophysiology; neuroanatomy; neurophysiology; sinoatrial node.