The Journal of Thoracic and Cardiovascular Surgery
Volume 163, Issue 2, February 2022, Pages e113-e122
Thoracic: Lung Transplant: Basic ScienceProtective effect of necrosulfonamide on rat pulmonary ischemia-reperfusion injury via inhibition of necroptosis
Under an Elsevier user license
open archive
Graphical abstract
Key Words
ischemia-reperfusion injury
cell death
apoptosis
necrosis
necroptosis
necrosulfonamide
receptor-interacting protein kinase-1
receptor-interacting protein kinase-3
mixed lineage kinase domain-like protein
Abbreviations and Acronyms
DAMP
damage-associated molecular pattern
DAPI
4′,6-diamidino-2-phenylindole
DMSO
dimethyl sulfoxide
ELISA
enzyme-linked immunoassay
HMGB1
high-mobility group box protein 1
HPF
high-power field
IL
interleukin
IRI
ischemia-reperfusion injury
MLKL
mixed-lineage kinase domain-like protein
Nec-1
necrostatin-1
NSA
necrosulfonamide
RIPK1
receptor-interacting protein kinase-1
RIPK3
receptor-interacting protein kinase-3
TNF-α
tumor necrosis factor alpha
TUNEL
terminal deoxynucleotidyl transferase-dUTP nick-end labeling
TV
tidal volume
Cited by (0)
© 2021 by The American Association for Thoracic Surgery