miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

Circ Res. 2021 Apr 16;128(8):1122-1138. doi: 10.1161/CIRCRESAHA.120.317914. Epub 2021 Feb 17.

Authors

Milessa Silva Afonso^{1

2}, Monika Sharma^{1

2}, Martin Schlegel^{1

2

3}, Coen van Solingen^{1

2}, Graeme J Koelwyn^{1

2}, Lianne C Shanley^{1

2}, Lauren Beckett¹, Daniel Peled^{1

2}, Karishma Rahman^{1

2}, Chiara Giannarelli⁴, Huilin Li⁵, Emily J Brown^{1

2}, Alireza Khodadadi-Jamayran⁶, Edward A Fisher^{1

2}, Kathryn J Moore^{1

2}

Affiliations

¹ Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (M.S.A., M. Sharma, M. Schlegel, C.v.S., G.J.K., L.C.S., L.B., D.P., K.R., E.J.B., E.A.F., K.J.M.).
² NYU Cardiovascular Research Center (M.S.A., M. Sharma, M. Schlegel, C.v.S., G.J.K., L.C.S., L.B., D.P., K.R., E.J.B., E.A.F., K.J.M.), New York University School of Medicine.
³ Department of Anesthesiology and Intensive Care, Technical University of Munich School of Medicine, Germany (M. Schlegel).
⁴ Cardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (C.G.).
⁵ Division of Biostatics, Department of Population Health (H.L), New York University School of Medicine.
⁶ Applied Bioinformatics Laboratories (A.K.-J.), New York University School of Medicine.

Abstract

[Figure: see text].

Keywords: adaptive immunity; atherosclerosis; inflammation; macrophages; microRNA.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Lipid Metabolism
Macrophages / metabolism
Male
Mice
Mice, Inbred C57BL
MicroRNAs / genetics
MicroRNAs / metabolism*
Monocytes / metabolism*
Plaque, Atherosclerotic / genetics*
Plaque, Atherosclerotic / immunology
T-Lymphocytes / metabolism*
Transcriptome

Substances

MicroRNAs
Mirn33 microRNA, mouse

Grants and funding