LncRNA ZNF593-AS Alleviates Contractile Dysfunction in Dilated Cardiomyopathy

Circ Res. 2021 May 28;128(11):1708-1723. doi: 10.1161/CIRCRESAHA.120.318437. Epub 2021 Feb 8.

Abstract

[Figure: see text].

Keywords: calcium; cardiomyopathies; gene expression; heart failure; therapeutics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta
  • Calcium / metabolism
  • Cardiomyopathy, Dilated / complications
  • Cardiomyopathy, Dilated / genetics
  • Cardiomyopathy, Dilated / metabolism*
  • Cytoplasm / metabolism
  • DNA-Binding Proteins / analysis
  • DNA-Binding Proteins / antagonists & inhibitors
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Heart Failure / etiology
  • Heart Failure / metabolism
  • Heterogeneous-Nuclear Ribonucleoprotein Group C / metabolism
  • Humans
  • Mice
  • Myocardial Contraction*
  • Myocytes, Cardiac / drug effects
  • Myocytes, Cardiac / metabolism
  • Phenylephrine / pharmacology
  • RNA, Long Noncoding / analysis
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism*
  • RNA, Messenger / metabolism
  • Ryanodine Receptor Calcium Release Channel / genetics
  • Ryanodine Receptor Calcium Release Channel / metabolism
  • Tissue Array Analysis
  • Transcription Factors / analysis
  • Transcription Factors / antagonists & inhibitors
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Vasoconstriction

Substances

  • DNA-Binding Proteins
  • HNRNPC protein, human
  • Heterogeneous-Nuclear Ribonucleoprotein Group C
  • RNA, Long Noncoding
  • RNA, Messenger
  • RyR2 protein, human
  • Ryanodine Receptor Calcium Release Channel
  • Transcription Factors
  • ZNF593 protein, human
  • Zfp593 protein, mouse
  • Phenylephrine
  • Calcium