MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+ Leak

Circ Res. 2021 Apr 16;128(8):1191-1204. doi: 10.1161/CIRCRESAHA.120.318562. Epub 2021 Feb 1.

Abstract

[Figure: see text].

Keywords: genetic therapy; guinea pigs; heart failure; reactive oxygen species; ryanodine receptor calcium release channel; sudden cardiac death.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / genetics
  • Calcium Channels / metabolism*
  • Calcium Signaling
  • Death, Sudden, Cardiac / etiology
  • Guinea Pigs
  • Heart Failure / metabolism*
  • Membrane Potential, Mitochondrial
  • Mitochondria, Heart / metabolism*
  • Myocytes, Cardiac / metabolism
  • Sarcoplasmic Reticulum / metabolism*
  • Up-Regulation

Substances

  • Calcium Channels
  • mitochondrial calcium uniporter
  • Calcium