Cardiac troponin and defining myocardial infarction

Cardiovasc Res. 2021 Aug 29;117(10):2203-2215. doi: 10.1093/cvr/cvaa331.

Abstract

The 4th Universal Definition of Myocardial Infarction has stimulated considerable debate since its publication in 2018. The intention was to define the types of myocardial injury through the lens of their underpinning pathophysiology. In this review, we discuss how the 4th Universal Definition of Myocardial Infarction defines infarction and injury and the necessary pragmatic adjustments that appear in clinical guidelines to maximize triage of real-world patients.

Keywords: Myocardial infarction; Myocardial injury; Troponin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood
  • Consensus
  • Decision Support Techniques
  • Humans
  • Myocardial Infarction / blood
  • Myocardial Infarction / classification
  • Myocardial Infarction / diagnosis*
  • Myocardial Infarction / therapy
  • Practice Guidelines as Topic
  • Predictive Value of Tests
  • Prognosis
  • Terminology as Topic*
  • Troponin / blood*

Substances

  • Biomarkers
  • Troponin