Comparison of Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting Among Patients With Three-Vessel Coronary Artery Disease in the New-Generation Drug-Eluting Stents Era (From CREDO-Kyoto PCI/CABG Registry Cohort-3)
Section snippets
Methods
The Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) PCI/CABG registry Cohort-3 is a physician-initiated, non-company-sponsored, multicenter registry enrolling consecutive patients who underwent first coronary revascularization with PCI or isolated CABG without combined noncoronary surgery among 22 Japanese centers between January 2011 and December 2013 (Supplementary Appendix). Both PCI and CABG were available in 16 centers, while there was no cardiovascular
Results
The current study population consisted of 1747 patients (69%) who underwent PCI, and 778 patients (31%) who underwent CABG (Figure 1). Among 2248 patients who were enrolled from those centers with both PCI and CABG facilities, there were 1470 (65%) patients treated with PCI, and 778 (35%) treated with CABG.
Patients in the PCI group was significantly older and more often had severe frailty and malignancy, but not active malignancy, than those in the CABG group, whereas patients in the CABG group
Discussion
The main findings of this study comparing PCI with CABG in patients with 3VD in the new-generation DES era were as follows; (1) In the present study population reflecting real-world clinical practice in Japan between 2011 and 2013, PCI was the preferred modality of coronary revascularization used in almost two-thirds of patients with 3VD; (2) PCI compared with CABG was associated with significantly higher risk for all-cause death, which was mainly driven by the excess risk for
Author Credit Statement
Yukiko Matsumura-Nakano: Methodology, Formal analysis, Investigation, Data curation, Writing-Original Draft; Hiroki Shiomi: Methodology, Investigation, Data curation, Writing-Review and Editing, Supervision, Project administration; Takeshi Morimoto: Methodology, Formal analysis, Writing-Review and Editing, Supervision; Kyohei Yamaji: Investigation, Resources, Writing-Review and Editing; Natsuhiko Ehara: Investigation, Resources; Hiroki Sakamoto: Investigation, Resources; Yasuaki Takeji:
Disclosures
Dr. Shiomi reports honoraria from Abbott Vascular, and Boston Scientific. Dr. Morimoto reports honoraria from Bayer and Kowa, and expert witness from Boston Scientific and Sanofi. Dr. Ehara reports honoraria from Abbott Vascular, Bayer, Boston Scientific, Medtronic, and Terumo. Dr. Furukawa reports honoraria from Bayer, Kowa, and Sanofi. Dr. Nakagawa reports research grant from Abbott Vascular and Boston Scientific, and honoraria from Abbott Vascular, Bayer, and Boston Scientific. Dr. Kimura
Declaration of Interests
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this study.
Acknowledgment
We thank the clinical research coordinators of the Research Institute for Production Development.
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Coronary Artery Disease Without Standard Cardiovascular Risk Factors
2022, American Journal of CardiologyIschemic and Bleeding Events After First Major Bleeding Event in Patients Undergoing Coronary Stent Implantation
2022, American Journal of CardiologyCitation Excerpt :Baseline characteristics were not evaluated at the time of the first major bleeding but were evaluated at the time of index PCI. Definitions for baseline characteristics were described previously.3 Baseline data were collected from hospital charts according to the prespecified definitions by the experienced clinical research coordinators in an independent clinical research organization.
Stent-Related Adverse Events as Related to Dual Antiplatelet Therapy in First- vs Second-Generation Drug-Eluting Stents
2021, JACC: AsiaCitation Excerpt :The study group consisted of a series of large Japanese registries: the CREDO-Kyoto PCI/CABG (Coronary Revascularization Demonstrating Outcome Study in Kyoto Percutaneous Coronary Intervention/Coronary Artery Bypass Grafting) Registry Cohort-2 and Cohort-3. These physician-initiated non–company-sponsored multicenter registries consecutively enrolled patients who underwent their first coronary revascularization with PCI or isolated CABG: Cohort-2 in 26 centers between January 2005 and December 2007 (after approval of G1-DES) and Cohort-3 in 22 centers between January 2011 and December 2013 (after approval of G2-DES) (Supplemental Appendix) (23,24). The relevant Institutional Review Boards at all participating hospitals approved the study protocols, and we performed the studies in accordance with the Declaration of Helsinki.
Sources of funding: This study was supported by an educational grant from the Research Institute for Production Development (Kyoto, Japan).