Images That TeachTc-99m HMDP bone scintigraphy for cardiac amyloidosis diagnosis: A false positive case
Introduction
Transthyretin-related cardiac amyloidosis is a common and probably underestimated cause of heart failure in the elderly population.
Tc-99m hydroxy-methyl-diphosphonate scintigraphy is one of the exams that can help clinicians to make the diagnosis.
There is no cause of false positive heart uptake described in the literature.
Section snippets
Case presentation
A 68-year-old man with heart failure (left ventricular ejection fraction = 30%) and normal coronary angiography underwent bone scintigraphy for suspected transthyretin-related cardiac amyloidosis (CA).1 He received 532 MBq (14.3 mCi) Tc-99m hydroxy-methyl-diphosphonate (HMDP) and data were acquired 2 hours after injection. On anterior and posterior whole-body scans (Figure 1A and B), diffuse cardiac, hepatic, and soft-tissue uptake of the radiotracer was seen, in association with low skeletal
Disclosures
Guillaume Lades, Helene Carpenet, Victor Aboyans, and Jacques Monteil have nothing to disclose.
Funding
None declared.
References (3)
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Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy
J Am Coll Cardiol
(2005)
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