Circadian effects on stroke outcome - Did we not wake up in time for neuroprotection?

J Cereb Blood Flow Metab. 2021 Mar;41(3):684-686. doi: 10.1177/0271678X20978711. Epub 2020 Dec 18.

Abstract

The occurrence of stroke in humans peaks in the morning. A recent study revealed that time of day mitigates the therapeutic impact of neuroprotective paradigms. These findings might not only explain the previous failure of translation of neuroprotective therapies but inspire new paradigms in stroke chronopathophysiology research. Taking chronotype into account may complement the many factors that influence efficacy of experimental therapies in stroke.

Keywords: Stroke; animal models; chronobiology. translational research; neuroprotection.

MeSH terms

  • Animals
  • Blood Pressure
  • Circadian Clocks / physiology*
  • Circadian Rhythm
  • Disease Models, Animal
  • Leukocytes / cytology
  • Leukocytes / metabolism
  • Neuroprotection
  • Stroke / pathology*