Original InvestigationThe Effect of Blood Lipids on the Left Ventricle: A Mendelian Randomization Study
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Central Illustration
Key Words
cardiac remodeling
cardiovascular risk
cholesterol
lipids
Mendelian randomization
Abbreviations and Acronyms
BMI
body mass index
BSA
body surface area
CI
confidence interval
CMR
cardiovascular magnetic resonance
EDV
end-diastolic volume
EF
ejection fraction
GLGC
Global Lipids Genetic Consortium
GRS
genetic risk score
Hb
hemoglobin
HDL
high-density lipoprotein
IVW
inverse-variance weighted
LDL
low-density lipoprotein
LV
left ventricle
MR
Mendelian randomization
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The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC author instructions page.
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Drs. Aung and Sanghvi contributed equally to this work and are co-first authors.
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Drs. Munroe and Petersen contributed equally to this work and are co-senior authors.
© 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.