Original InvestigationRandomized Trial of Empagliflozin in Nondiabetic Patients With Heart Failure and Reduced Ejection Fraction
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Central Illustration
Key Words
cardiac magnetic resonance
clinical trial
heart failure
LV remodeling
SGLT2-inhibitors
Abbreviations and Acronyms
6MWT
6-min walk test
CMR
cardiac magnetic resonance
CPET
cardiopulmonary exercise test
HFrEF
heart failure with reduced ejection fraction
KCCQ-12
Kansas City Cardiomyopathy Questionnaire
LV
left ventricle/ventricular
LVEDV
left ventricular end-diastolic volume
LVEF
left ventricle ejection fraction
LVESV
left ventricular end-systolic volume
OUES
oxygen uptake efficiency slope
SGLT2i
sodium-glucose cotransporter 2 inhibitors
VO2
oxygen consumption
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Lee R. Goldberg, MD, MPH, served as Guest Associate Editor for this paper. Athena Poppas, MD, served as Guest Editor-in-Chief for this paper.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the Author Center.
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Drs. Santos-Gallego and Vargas-Delgado contributed equally to this work.
© 2021 by the American College of Cardiology Foundation. Published by Elsevier.