Focus Issue: Mechanistic Insights and Drug TherapyOriginal ResearchSoluble Neprilysin and Corin Concentrations in Relation to Clinical Outcome in Chronic Heart Failure
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Central Illustration
Key Words
clinical outcome
corin
heart failure
natriuretic peptide
neprilysin
Abbreviations and Acronyms
aHR
adjusted hazard ratio
ANP
atrial natriuretic peptide
ARNI
Angiotensin-receptor-neprilysin inhibitor
BNP
B-type natriuretic peptide
CI
confidence interval
CV
cardiovascular
ELISA
enzyme-linked immunosorbent assay
HF
heart failure
HFpEF
heart failure with preserved ejection fraction
HFrEF
heart failure with reduced ejection fraction
IQR
interquartile range
NEP
neprilysin
NP
natriuretic peptide
NT-proBNP
N-terminal pro–B-type natriuretic peptide
proANP
pro-atrial natriuretic peptide
proBNP
pro-B-type natriuretic peptide
sCOR
soluble corin
sNEP
soluble neprilysin
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Drs. Bayés-Genis and R.J. van Kimmenade contributed equally and are joint senior authors.
© 2021 by the American College of Cardiology Foundation. Published by Elsevier.