Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes
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Graphical abstract
Keywords
Cardiomyopathy
Hypertrophic cardiomyopathy
Troponin
Troponin T
TNNT2
Myofilament
Mutation
Mutation location
Mutant protein dose
Human tissue
Troponin exchange
Protein level
Ca2+-sensitivity
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