Elsevier

Resuscitation

Volume 157, December 2020, Pages 248-258
Resuscitation

Review
Incidence and outcome of out-of-hospital cardiac arrests in the COVID-19 era: A systematic review and meta-analysis

https://doi.org/10.1016/j.resuscitation.2020.10.025Get rights and content

Abstract

Background

The impact of COVID-19 on pre-hospital and hospital services and hence on the prevalence and outcomes of out-of-hospital cardiac arrests (OHCA) remain unclear. The review aimed to evaluate the influence of the COVID-19 pandemic on the incidence, process, and outcomes of OHCA.

Methods

A systematic review of PubMed, EMBASE, and pre-print websites was performed. Studies reporting comparative data on OHCA within the same jurisdiction, before and during the COVID-19 pandemic were included. Study quality was assessed based on the Newcastle-Ottawa Scale.

Results

Ten studies reporting data from 35,379 OHCA events were included. There was a 120% increase in OHCA events since the pandemic. Time from OHCA to ambulance arrival was longer during the pandemic (p = 0.036). While mortality (OR = 0.67, 95%-CI 0.49−0.91) and supraglottic airway use (OR = 0.36, 95%-CI 0.27−0.46) was higher during the pandemic, automated external defibrillator use (OR = 1.78 95%-CI 1.06–2.98), return of spontaneous circulation (OR = 1.63, 95%CI 1.18-2.26) and intubation (OR = 1.87, 95%-CI 1.12-–3.13) was more common before the pandemic. More patients survived to hospital admission (OR = 1.75, 95%-CI 1.42–2.17) and discharge (OR = 1.65, 95%-CI 1.28–2.12) before the pandemic. Bystander CPR (OR = 1.18, 95%-CI 0.95-1.46), unwitnessed OHCA (OR = 0.84, 95%-CI 0.66–1.07), paramedic-resuscitation attempts (OR = 1.19 95%-CI 1.00–1.42) and mechanical CPR device use (OR = 1.57 95%-CI 0.55–4.55) did not defer significantly.

Conclusions

The incidence and mortality following OHCA was higher during the COVID-19 pandemic. There were significant variations in resuscitation practices during the pandemic. Research to define optimal processes of pre-hospital care during a pandemic is urgently required.

Review registration

PROSPERO (CRD42020203371).

Keywords

COVID-19
SARS-CoV-2
Out of hospital
Cardiac arrest
OHCA

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