MitraClip in secondary mitral regurgitation as a bridge to heart transplantation: 1-year outcomes from the International MitraBridge Registry
Section snippets
Registry study design
MitraBridge is a multicenter observational registry, including all consecutive patients with chronic advanced HF (defined as New York Heart Association [NYHA] III or IV and/or left ventricular ejection fraction [LVEF] ≤ 30% and according to the recently updated definitions proposed by the Heart Failure Association of the European Society of Cardiology3) and concomitant moderate-to-severe or severe secondary (or functional) MR being potential candidates for HTx. The registry was initiated in
Study population and demographics
In the MitraBridge registry, 119 patients with moderate-to-severe or severe secondary MR and advanced HF across 17 centers (in Italy, Switzerland, the Netherlands, Spain, and Canada) have been included. The median age of the treated population was 58 years (25th–75th percentile: 51–63 years), with 59% of patients ≤60 years old. Before MitraClip procedure, all patients were on guideline-directed medical therapy as tolerated (Table 1). Hospitalization for HF within the previous 6 months was
Discussion
This is a multicenter, international registry reporting data in patients with advanced HF with significant secondary MR and the MitraClip procedure as a bridge to transplant strategy. The main findings demonstrate the following: (1) the selected use of MitraClip as a bridge strategy to HTx was safe (87.5% procedural success and no death at 30 days) and effective; (2) two thirds of patients remain free of development of composite adverse events at 1 year (primary end-point); (3) 15.5% became
Disclosure statement
Dr Rodrigo Estévez-Loureiro reports receiving grants and personal fees from Abbott during the conduct of the study. The remaining authors have no conflicts of interest to declare.
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