Longitudinal Strain and Strain Rate for Estimating Left Ventricular Filling Pressure in Heart Transplant Recipients
Section snippets
Methods
All OHT patients followed from January 2017 to December 2019 at our center were included consecutively at the time of surveillance endomyocardial biopsies regardless of symptoms according to our institutional follow-up protocol.9 Patients were excluded if they had biatrial anastomoses (n = 2) or inadequate image quality for strain analysis (n = 2). All were in normal sinus rhythm, had no conduction abnormality, pericardial effusion or more than mild valvular disease. We excluded examinations
Results
A total of 74 data sets were obtained from 50 patients after OHT. Patients’ characteristics are presented in Table 1. Twenty-four patients had 2 studies at different time points with different hemodynamic measurements. In all, PCWP was 11.8 ± 4.3 mm Hg (range 4 to 25), systolic PAP 27.2 ± 7.9 mm Hg (range 8 to 59), mean PAP 17.1 ± 5.9 mm Hg (range 7 to 47), right atrial pressure 5.7 ± 4.0 mm Hg (range 1 to 18). In the pooled dataset LV EF, GLS, SSR, e’SR were significantly decreased while LV
Discussion
The main findings of the present study can be summarized as follows: SSR, e’SR, E/e’SR, and GLS are worsening in OHT patients with elevated LVFP and have clearly stronger diagnostic performance than traditional parameters of diastolic dysfunction, even though E/e’ performs well to predict elevated LVFP in native failing hearts of the same patients. Moreover, E/e’SR and GLS are associated with LVFP independently from LV EF, EDVi and allograft vasculopathy. Finally, changes in GLS and E/e'SR
Authors contribution
All authors have read and approved the manuscript. All authors have access to the full dataset. The authors have no conflict of interest related to this manuscript.
Dr Colak took part in reviewing echocardiographic data and drafting the manuscript. Dr Muderrisoglu contributed to the design and revision of the manuscript, Dr Eroglu and Dr Pirat took part in reviewing echocardiographic data, Dr Aydınalp took part in reviewing catheter data, Dr Sezgin took part in final approval and Dr Sade took
Disclosures
None of the authors have anything to disclose.
Declaration of Interest
The authors declare that they have no known competing financial interests or personal relations that could have appeared to influence the work reported in this study.
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All financial support related to this study is provided by the University of Baskent, KA 13/03.