Original ResearchAldosterone-Related Myocardial Extracellular Matrix Expansion in Hypertension in Humans: A Proof-of-Concept Study by Cardiac Magnetic Resonance
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Central Illustration
Key Words
extracellular matrix
cardiac magnetic resonance
myocardial fibrosis
myocardial remodeling
primary hyperaldosteronism
Abbreviations and Acronyms
BG
Bartter/Gitelman syndrome
BP
blood pressure
CMR
cardiovascular magnetic resonance
ECM
extracellular mass
ECV
extracellular volume
HS
healthy subjects
HTN
hypertension
ICM
intracellular mass
ICV
intracellular volume
LV
left ventricular
LVM
left ventricular mass
PA
primary aldosteronism
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This work was funded by the “Contrat de Recherche Clinique from the Assistance Publique des Hôpitaux de Paris” and the French Ministry of Health (2012-A00615-38). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Cardiovascular Imaging author instructions page.
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Drs. Redheuil and Blanchard contributed equally to this work.
© 2020 by the American College of Cardiology Foundation. Published by Elsevier.