Cardiovascular Risk Among Patients ≥65 Years of Age with Parkinson's Disease (From the National Inpatient Sample)
Section snippets
Method
This study was conducted using the National Inpatient Sample (NIS) of the Health Care Utilization Project sponsored by the Agency for Healthcare Research and Quality.4 The NIS is a publicly available national registry that receives data from all US community hospital discharges. The NIS includes administrative as well as demographic data from a 20% sample of inpatient hospitalizations in the United States. NIS provides hospitalization information for over 7 million hospital stays each year with
Results
Table 1 summarizes the baseline characteristics of the study population. Overall a total of 57,914 patients (weighted: 289,570) with PD were included. Most patients were of the white race (80.8%). Women were 42.4% and the mean age was 79 years, standard error of the mean (0.03). Sepsis was the most common reason for admission for patients with and without PD (Supplementary Table 1). The results of the multivariable analysis were summarized in (Table 2). PD correlated with lower odds for
Discussion
The main findings of our study are plausibly explained by the impact of low sympathetic tone on cardiovascular factors among patients with PD. We found that patients with PD have a lower prevalence of diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease (CAD), and a higher prevalence of stroke.
The sympathetic nervous system maintains homeostasis and plays a pivotal role in the dynamics of cardiovascular risk factors and co-morbidities. It is typically activated during stress
Authors Contribution
AA: conceptualization, methodology, resources, formal analysis, visualization, writing - original draft. AT: writing - review & editing. MA: formal analysis, review & editing. PP: Writing - review & editing. IA: writing - review & editing. LK: supervision, writing - review & editing.
Disclosures
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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