Brief ReportFirst-in-human imaging and kinetic analysis of vesicular acetylcholine transporter density in the heart using [18F]FEOBV PET
Section snippets
New Knowledge Gained
[18F]FEOBV appears to be a viable tracer for the assessment of cholinergic (parasympathetic) activity in the heart using non-invasive PET imaging.
Conclusion
[18F]FEOBV PET is a promising radioligand to assess cholinergic activity in the heart and may become a useful non-invasive method to study cardiac parasympathetic function and improve risk assessment and prognosis in cardiac patients with conditions associated with autonomic imbalance or impaired parasympathetic activity.
Acknowledgements
This study was supported by the University of Ottawa Medical Research Fund and the Royal’s Institute of Mental Health Research Brain Imaging Centre.
Disclosures
Zacharie Saint-Georges, Vanessa Zayed, Katie Dinelle, Clifford Cassidy, Jean-Paul Soucy, Gassan Massarweh, Benjamin Rotstein, Pablo Nery, Synthia Guimond, Robert deKemp, and Lauri Tuominen have nothing to declare.
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