Cardiotoxic mechanisms of cancer immunotherapy – A systematic review
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open access
Keywords
Cancer immunotherapy
Cardiovascular toxicity
Cardiooncology
Translational medicine
Abbreviations
ADCC
Antibody dependent cellular cytotoxicity
ALCL
Anaplastic large cell lymphoma
ALL
Acute lymphatic leukemia
AMPK
AMP activated kinase
APC
Antigen presenting cells
BcG
Bacillus-Calmette Guerin
BiTE
Bispecific T-cell engager
CAR
Chimeric Antigen Receptor
CEA
Carcinoembryonic Antigen
CD
Cluster of Differentiation
CHF
Chronic heart failure
CLL
Chronic lymphatic leukemia
CMP
Cardiomyopathy
c-Raf
RAF proto-oncogene serine/threonine-protein kinase
CRS
Cytokine Release Syndrome
CTL-4
cytotoxic T-lymphocyte-associated Protein 4
DAMP
Danger associated molecular pattern
DC
Dendritic cell
DLBCL
Diffuse large B-cell lymphoma
ErbB
Erythroblastosis virus oncogene B
EGFR
Epidermal growth factor receptor
FGF
Fibroblast growth factor receptor
Flt-3
Fms-like tyrosine kinase 3
HL
Hodgkin Lymphoma
IFN
Interferon
IL-2
Interleukin 2
IL-6
Interleukin 6
IL-12
Interleukin 12
KRAS
Kirsten rat sarcoma viral oncogen
LV-EF
Left ventricular ejection fraction
LPS
Lipopolysaccharide
mAb
Monoclonal Antibody
MAGE-A3
Melanoma Antigen-A3
MCP-1
Monocyte chemoattractant protein-1
MHC-I
Major Histocompatibility Complex I
MIP-α
Macrophage inflammatory protein alpha
NSTEMI
non ST-elevated myocardial infarction
NK-cells
Natural killer cells
NHL
Non-Hodgkin Lymphoma
NSCLC
Non-Small Cell Lung Cancer
NO
Nitric oxide
PAMP
Pathogen associated molecular pattern
PBMC
Peripheral blood mononuclear cell
PDGF
Platelet derived growth factor
PD-1
Programmed cell death protein 1
PD-L1
Programmed death-ligand 1
PRR
Pattern recognition receptor
ROS
Reactive oxygen species
scFv
single chain variable fragments
SIRS
Systemic inflammatory response syndrome
SLE
Systemic lupus erythematodes
TAA
Tumour associated antigen
TKI
Tyrosine kinase inhibitor
TLR
Toll like receptor
TNF-α
Tumour necrosis factor alpha
VEGF
Vascular endothelial growth factor
VEGFR
Vascular endothelial growth factor receptor
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© 2020 The Authors. Published by Elsevier B.V.