Late Adverse Cardiorenal Events of Catheter Procedure-Related Acute Kidney Injury After Transcatheter Aortic Valve Implantation
Section snippets
Methods
Data were extracted from the Optimized CathEter vAlvular iNtervention (OCEAN)-TAVI registry.12, 13 The OCEAN-TAVI registry is an ongoing multicenter registry collecting data from 14 Japanese medical centers including Kishiwada Tokusyukai Hospital.12, 13 A total of 2,588 patients underwent baseline, peri-, and postoperative data collection before undergoing TAVI between October 2013 and May 2017. All patients who underwent TAVI in each center were considered in the initial inclusion in this
Results
AKI occurred in 243 of 2,518 patients (9.7%). The patient baseline characteristics are shown in Table 1. The proportion of men patients was 30.5%, and the mean age was 84.3 ± 5.2 years. Several baseline characteristics differed between the AKI and non-AKI groups. The baseline SCr value was higher and eGFR was lower in the AKI group than in the non-AKI group (1.39 ± 0.8 mg/dl vs 0.99 ± 0.4 mg/dl, p <0.001, 51.6 ± 19.4 ml/min/1.73 m2 vs 52.7 ± 19.1 ml/min/1.73 m2, p = 0.04, respectively). As a
Discussion
The results of our study demonstrated the clinical impact of AKI on the long-term cardiac adverse events after TAVI. Although the longitudinal clinical effect of catheter-related AKI has not been well established, the occurrence of AKI significantly increased the rates of HF readmission, future hemodialysis, cardiac death, and all-cause mortality. AKI-related complications negatively affect both cardiac and renal function; this supports the concept of cardiorenal syndrome.10, 11 Even after a
Authors’ Contributions
Yuya Adachi: Conceptualization, Methodology, Software, Formal analysis, Visualization. Masanori Yamamoto: Data curation, Writing - Review and Editing, Supervision. Tetsuro Shimura: Resources, Data curation. Ryo Yamaguchi: Resources, Data curation. Ai Kagase: Resources, Data curation. Takahiro Tokuda: Resources, Data curation. Satoshi Tsujimoto: Resources, Data curation. Yutaka Koyama: Resources, Data curation. Toshiaki Otsuka: Software, Validation, Formal analysis. Fumiaki Yashima:
Disclosures
Drs. Yamamoto, Tada, Naganuma, Shirai, Mizutani, and Watanabe are clinical proctors for Edwards Lifesciences and Medtronic. Drs. Araki, Tabata, Takagi, Higashimori, and Hayashida are clinical proctors of Edwards Lifesciences. Dr. Ueno is a clinical proctor for Medtronic. The remaining authors have nothing to disclose.
Acknowledgment
The authors thank the investigators and institutions that have participated in the OCEAN-TAVI registry.
References (19)
- et al.
Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the NCDR Cath-PCI registry
JACC Cardiovasc Interv
(2014) - et al.
Renal function-based contrast dosing predicts acute kidney injury following transcatheter aortic valve implantation
JACC Cardiovasc Interv
(2013) - et al.
Transcatheter aortic valve replacement outcomes in Japan: Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry
Cardiovasc Revasc Med
(2019) - et al.
Volume-to-creatinine clearance ratio: a pharmacokinetically based risk factor for prediction of early creatinine increase after percutaneous coronary intervention
J Am Coll Cardiol
(2007) - et al.
Recovery of kidney dysfunction after transcatheter aortic valve implantation (from the Northern New England Cardiovascular Disease Study Group)
Am J Cardiol
(2019) - et al.
Contrast-induced acute kidney injury and adverse clinical outcomes risk in acute coronary syndrome patients undergoing percutaneous coronary intervention: a meta-analysis
BMC Nephrol
(2018) - et al.
Acute kidney injury following peripheral angiography and endovascular therapy: a systematic review of the literature
Catheter Cardiovasc Interv
(2016) - et al.
Predictors and outcome of acute kidney injury after transcatheter aortic valve implantation: a systematic review and meta-analysis
EuroIntervention
(2017) - et al.
Acute kidney injury after aortic valve replacement: incidence, risk factors and outcomes
Expert Rev Cardiovasc Ther
(2015)
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Funding: The OCEAN-TAVI registry is supported by Edwards Lifesciences, Medtronic, and Daiichi-Sankyo Company.