The 'wait for symptoms' strategy in asymptomatic severe aortic stenosis

Heart. 2020 Dec;106(23):1792-1797. doi: 10.1136/heartjnl-2020-317323. Epub 2020 Aug 3.

Abstract

Calcific aortic stenosis is a prevalent and worrisome healthcare problem. The therapeutic approach in asymptomatic aortic stenosis is not well established. We argue that the natural history of this disease is based on old incomplete studies with many limitations. Likewise, studies suggesting that replacement, either surgical or percutaneous, improves prognosis in asymptomatic patients with severe aortic stenosis have important drawbacks and do not support this strategy as the treatment of choice. Despite the lack of evidence, some groups recommend early valve replacement in patients with severe asymptomatic aortic stenosis. There are five ongoing randomised trials which will shed light on this topic. Our conclusion is that unless a randomised study changes the evidence, valve replacement cannot be recommended in asymptomatic patients with severe aortic stenosis.

Keywords: aortic stenosis; valve disease surgery.

Publication types

  • Review

MeSH terms

  • Aortic Valve Stenosis* / diagnosis
  • Aortic Valve Stenosis* / physiopathology
  • Aortic Valve Stenosis* / surgery
  • Asymptomatic Diseases / therapy*
  • Heart Valve Prosthesis Implantation* / adverse effects
  • Heart Valve Prosthesis Implantation* / methods
  • Humans
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Severity of Illness Index
  • Time-to-Treatment / standards*