ORIGINAL CLINICAL SCIENCEIncidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: Analysis of ISHLT Registry
Section snippets
Study design
We analyzed the ISHLT Registry, an international longitudinal voluntary database that incorporates country and consortium transplant data reported by individual centers. A total of 260 lung transplant centers report to the ISHLT Registry, representing approximately 75% of the worldwide transplant activity.
Primary end-points and covariables
The primary end-point of interest was time to development of PTLD after lung transplantation. Outcomes were evaluated at time of yearly follow-up. Primary end-point was censored at last
Patient characteristics
ISHLT Registry data for 49,776 lung transplants performed between January 2006 and December 2016 were included. We excluded from analysis 3,852 LTRs with <1 year of follow-up, 1,392 LTRs receiving retransplantation, 21 LTRs receiving lobar lung transplant, 1,463 patients younger than 18 years of age, and 23,739 LTRs from centers not reporting PTLD during follow-up (Figure 1). Thus, the analysis cohort included 19,309 adult first LTRs.
Clinical characteristics of the study cohort are described in
Discussion
PTLD is a rare but life-threatening complication following transplantation. Several single-center analyses have identified numerous risk factors associated with PTLD such as primary EBV infection, organ transplanted, age, Caucasian race, and CMV mismatch.9,19, 20, 21 However, these analyses are often limited by their small size. To our knowledge, for the first time with this study, we evaluated the incidence and identified pre- and peri-transplant clinical characteristics associated with PTLD
Disclosure statement
The authors have no conflict of interest to disclose.
This work was supported by the ISHLT Transplant Registry Early Career Award.
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