Focus Issue: Angiotensin-Neprilysin Inhibition: Novel InsightsState-of-the-Art ReviewSacubitril/Valsartan in Advanced Heart Failure With Reduced Ejection Fraction: Rationale and Design of the LIFE Trial
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Dr. Mann has served as a consultant for Novartis. Dr. Greene has received research support from Amgen, AztraZeneca, Bristol-Myers Squibb, Merck, and Novartis; and is a consultant for Amgen and Merck; is a member of the advisory boards of Amgen and Cytokinetics. Dr. Starling has served as a consultant for Novartis; and is on the steering committee for the PARAGLIDE trial. Dr. Ambrosy has received research support from Novartis; and has received personal fees for the PIONEER-HF trial. Dr. Shah is an employee of Inova Heart and Vascular Institute; has received grant support from Merck, Abbott, Bayer, Medtronic, and Pulse CV; and is a consultant for NuPulse, Ortho Clinical Diagnostics, and Procyrion. Dr. Mahr is a consultant for Abbott, Medtronic, and Abiomed. Dr. Lewis has been a consultant for and received research support from Cytokinetics and Applied Therapeutics; and received research support from Amgen and AstraZeneca. Dr. Mohammed is a member of the advisory board for Pfizer; and has received research support from Cardiocell, Abbott, Actelion, Corvia, and Medtronic. Dr. Gilotra is a consultant for scPharmaceuticals. Dr. DeVore has received research support through his institution from the American Heart Association, Amgen, AstraZeneca, Bayer, Intra-Cellular Therapies, American Regent, National Heart, Lung, Blood Institute, Novartis, and Patient-Centered Outcomes Research Institute; and is a consultant for Novartis. Dr. Desvigne-Nickens is an employee of the National Heart, Lung, and Blood Institute; and is a consultant for Novartis. Dr. Gorodeski has received research support and speaker and consultation compensation from Abbott. Dr. Hernandez has received research grants and consulting for AstraZeneca, Amgen, Bayer, Merck and Novartis. Dr. Braunwald has received research support through his institution from AstraZeneca, Daiichi-Sankyo, Merck, and Novartis; and is a consultant for Amgen, Cardurion, MyoKardia, and NovoNordisk. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute, the National Institute of Arthritis and Infectious Diseases, the National Institutes of Health, or the U.S. Department of Health and Human Services.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Heart Failure author instructions page.