Prior Carpal Tunnel Syndrome and Early Concomitant Echocardiographic Findings Among Patients With Cardiac Amyloidosis
Section snippets
Study Population
The population of the current study was comprised of consecutive patients with AL and ATTR treated at our institution (Rabin Medical Center, Israel) between 2008 and 2018. For all patients, electronic medical records, echocardiographic and nuclear scintigraphy scans were reviewed.
The diagnosis of AL was made in the presence of a monoclonal protein (identified by serum and urine protein immunofixation plus serum free light chain assay) and histologic evidence of amyloid deposition in tissue
Study Population
In total, 112 patients with systemic amyloidosis were identified during the study period. Four patients were excluded owing to suspected or confirmed amyloidosis at the time of CTS diagnosis. Therefore, our study population included 108 patients, of whom 82 (76%) had AL and 26 (24%) had ATTR. Cardiac amyloid involvement was diagnosed in 61% of patients (n = 66) with systemic amyloidosis (Table 1). Among the 82 patients with AL, 41 (50%) had cardiac involvement as determined by one or more
Discussion
This study evaluated the incidence of prior CTS diagnosis as well as concomitant echocardiographic parameters in a cohort of patients with systemic amyloidosis comprised of both AL and ATTR patients. We found that (1) CTS is a common finding (62%) in ATTR, and to a lesser extent AL (24%), and precedes the diagnosis of systemic amyloidosis by a median of 4 years, and (2) early echocardiographic findings concomitant with CTS diagnosis demonstrate increased wall thickness, LV mass, and LV
Funding
None
Disclosure of interest
None declared
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