Original InvestigationThe Natural History of Severe Calcific Mitral Stenosis
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Central Illustration
Key Words
echocardiography
mitral stenosis
valve disease
Abbreviations and Acronyms
CCI
Charlson Comorbidity Index
HR
hazard ratio
LVEF
left ventricle ejection fraction
MAC
mitral annulus calcification
MS
mitral stenosis
MVA
mitral valve area
RVSP
right ventricular systolic pressure
SMVR
surgical mitral valve replacement
TMG
transmitral gradient
TMVR
transcatheter mitral valve replacement
TTE
transthoracic echocardiography
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Dr. Pellikka has been supported as the Betty Knight Scripps Professor in Cardiovascular Disease Clinical Research. Dr. Guerrero has received research grant support from Abbott Vascular and Edwards Lifesciences. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC author instructions page.
© 2020 by the American College of Cardiology Foundation. Published by Elsevier.