Glucose fluctuations promote vascular BK channels dysfunction via PKCα/NF-κB/MuRF1 signaling
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Graphical abstract
Illustration showing the role of PKCα/NF-κB/MuRF1 signaling in the regulation of BK channel in response to glucose fluctuation.
Under conditions of glucose fluctuations, there is an activation of PKC, which in turn promotes NF-κB/p65 nuclear translocation, facilitates MuRF1-dependent BK-β1 protein degradation.
Keywords
Glucose fluctuation
Large conductance calcium activated potassium channel
Reactive oxygen species
Protein kinase Cα
Nuclear factor-κB
Muscle ring finger protein 1
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The two authors contributed equally to this work.
© 2020 The Authors. Published by Elsevier Ltd.