Original InvestigationLimitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease
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This publication is solely the responsibility of the authors and does not represent the views of the American Heart Association, National Institutes of Health/National Heart, Lung, and Blood Institute, Department of Veterans Affairs, or the United States government. Dr. Aragam is supported by an award from the American Heart Association Institute for Precision Cardiovascular Medicine (17IFUNP33840012). Dr. Chaffin is supported by a grant from Bayer AG to the Broad Institute focused on the development of therapeutics for cardiovascular disease. Dr. Weiss is supported in part by an NHGRI grant supporting the eMERGE Network (U01HG008685). Dr. Lubitz is supported by NIH grant 1R01HL139731 and American Heart Association 18SFRN34250007; has received research support from AstraZeneca and Goldfinch Bio, not related to this work; receives sponsored research support from Bristol-Myers Squibb/Pfizer, Bayer AG, and Boehringer Ingelheim; and has consulted for Bristol-Myers Squibb/Pfizer and Bayer AG. Dr. Smoller is supported in part by an NHGRI grant supporting the eMERGE Network (U01HG008685); and is an unpaid member of the Bipolar/Depression Research Community Advisory Panel of 23andMe. Dr. Karlson is supported in part by an NHGRI grant supporting the eMERGE Network (U01HG008685). Dr. Do is supported by R35GM124836 from the National Institute of General Medical Sciences of the National Institutes of Health, and R01HL139865 from the National Heart, Lung, and Blood Institute of the National Institutes of Health. Dr. Damrauer is supported by the U.S. Department of Veterans Affairs (IK2-CX001780); and has received research support to the University of Pennsylvania from CytoVas LLC and Renalytix AI, not related to this work. Dr. Natarajan is supported by grants from the National Heart, Lung, and Blood Institute (R01HL142711, R01HL148565, R01HL148050), Fondation Leducq (TNE-18CVD04), and Hassenfeld Scholar Award from the Massachusetts General Hospital; has received grant support from Amgen, Apple, and Boston Scientific; and is a scientific advisor to Apple. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Peter Ganz, MD, served as Guest Associate Editor for this paper. P.K. Shah, MD, served as Guest Editor-in-Chief for this paper.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC author instructions page.
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Drs. Aragam and Dobbyn contributed equally to this work.
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Drs. Damrauer and Natarajan jointly supervised this work.