Chest
Novel ReportsVenoocclusive Disease With Both Hepatic and Pulmonary Involvement
Section snippets
Case Report
We report a case of venoocclusive disease with hepatic and pulmonary involvement in a woman who had received HSCT. The 54-year-old woman was admitted to the hematology department with acute myeloid leukemia. Seven months later, she received allo-HSCT (unrelated donor) after two successive conditioning regimens including gemtuzumab and a pretransplant conditioning regimen including cyclophosphamide, busulfan, and fludarabine. Six days posttransplantation, she reported abdominal pain and rapid
Discussion
Diagnosis of PVOD and HVOD is challenging. Allo-HSCT, an unrelated donor, and use of gemtuzumab, busulfan, and cyclophosphamide are known risk factors for both diseases.2,11 The patient met European Society for Blood and Marrow Transplantation criteria for HVOD,2 with symptoms appearing within 21 days post-HSCT and elevated bilirubin. Diagnosis of PVOD was supported by precapillary PH, discrepancy between hemodynamic parameters and dyspnea, suggestive CT scan abnormalities, severe hypoxemia,
Acknowledgments
Financial/nonfinancial disclosures: The authors have reported to CHEST the following: D.M. reports grants and personal fees from Actelion and Bayer; personal fees from GSK, MSD, and Pfizer; and nonfinancial support from Jazz Pharmaceuticals, outside the submitted work. None declared (N.M., M.-F.S. B.D., T.S.).
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Cited by (0)
Drs Degano and Soumagne contributed equally to this work.