Original InvestigationHealth Status Changes and Outcomes in Patients With Heart Failure and Mitral Regurgitation: COAPT Trial
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The COAPT trial was sponsored by Abbott and designed collaboratively by the principal investigators and the sponsor. The present analysis was conducted by the first and last authors in conjunction with academic investigators at the Clinical Trials Center of the Cardiovascular Research Foundation. Dr. Stone has received consulting income from Neovasc, Gore, Ancora, and Valfix; and holds equity or options in Cardiac Success, Ancora, and Valfix. Dr. Mack has served as a co–primary investigator for the PARTNER trial for Edwards Lifesciences and the COAPT trial for Abbott; and has served as study chair for the APOLLO trial for Medtronic. Dr. Chhatriwalla is a member of the Speakers Bureau for Abbott, Edwards Lifesciences, and Medtronic; is a proctor for Edwards Lifesciences and Medtronic; and has received consulting income from Boston Scientific and Silk Road Medical. Dr. Kar has received research grant support from Abbott Vascular, Boston Scientific, Edwards Lifesciences, and Mitralign; and has received consulting income from Abbott Vascular and Boston Scientific. Dr. Lim has received research grant support and consulting income from Abbott Vascular. Dr. Lindenfeld has received research grant support from AstraZeneca; and has received consulting income from Abbott Vascular, Edwards Lifesciences, Boston Scientific, RESMED, Relypsa, Boehringer Ingelheim, and V-Wave. Dr. Abraham has received research grant support and consulting income from Abbott Vascular. Dr. Cohen has received research grant support from Abbott Vascular, Edwards Lifesciences, Medtronic, and Boston Scientific; and has received consulting income from Abbott Vascular, Edwards Lifesciences, Medtronic, and Boston Scientific. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Thomas Meinertz, MD, PhD, served as Guest Associate Editor for this paper.