Advanced Heart Failure in Adults With Congenital Heart Disease

Jonathan N Menachem; Kelly H Schlendorf; Jeremy A Mazurek; David P Bichell; D Marshall Brinkley; Benjamin P Frischhertz; Bret A Mettler; Ashish S Shah; Sandip Zalawadiya; Wendy Book; JoAnn Lindenfeld

doi:10.1016/j.jchf.2019.08.012

Advanced Heart Failure in Adults With Congenital Heart Disease

JACC Heart Fail. 2020 Feb;8(2):87-99. doi: 10.1016/j.jchf.2019.08.012. Epub 2019 Dec 11.

Affiliations

¹ Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: jonathan.n.menachem@vumc.org.
² Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
³ Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁴ Division of Pediatric Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
⁵ Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
⁶ Cardiovascular Medicine, Emory University School of Medicine, Atlanta, Georgia.

PMID: 31838031
DOI: 10.1016/j.jchf.2019.08.012

Abstract

As a result of improvements in care for patients with congenital heart disease (CHD), >90% of children born with CHD are expected to survive to adulthood. For those adults, heart failure (HF) is the leading cause of death. Advances in recognition of, and treatments for, these patients continue to improve. Specifically, adults with CHD are candidates for both heart transplantation and mechanical circulatory support. However, challenges remain that require investigation to improve outcomes.

Keywords: ACHD; congenital; heart; transplant; ventricular assist device.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Global Health
Heart Defects, Congenital / complications*
Heart Defects, Congenital / epidemiology
Heart Failure / epidemiology
Heart Failure / etiology*
Humans
Morbidity / trends