The association between lipid profiles and the neurologic outcome in patients with out-of-hospital cardiac arrest

Resuscitation. 2019 Dec:145:26-31. doi: 10.1016/j.resuscitation.2019.10.005. Epub 2019 Oct 15.

Abstract

Background: Lipid profiles are known to be a risk factor for development of cardiovascular disease. However, the relationship between lipid profiles and outcome in out-of-hospital cardiac arrest (OHCA) survivors remains unclear. We aimed to examine the association between lipid profiles and neurologic outcome in OHCA survivors.

Methods: This retrospective observational study included adult (≥18 years) OHCA survivors between January 2016 and December 2018. We measured patients' lipid profiles after return of spontaneous circulation (ROSC) including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride. The primary outcome was neurologic outcome at hospital discharge. Good neurologic outcome was defined cerebral performance categories 1 and 2.

Results: A total of 182 patients were included. Of them, 57 (31.3%) were discharged with good neurologic outcomes. Median serum levels of total cholesterol (178.0 vs. 123.0 mg/dL), HDL (44.0 vs. 31.0 mg/dL), and LDL (104.0 vs. 75.0 mg/dL) were significantly higher in patients with good neurologic outcome. The area under the curves of total cholesterol, HDL, LDL, and triglyceride were 0.742 (95% confidence interval [CI], 0.672-0.803), 0.729 (95% CI, 0.658-0.792), 0.683 (95% CI, 0.610-0.750), and 0.572 (95% CI, 0.497-0.645), respectively. Total cholesterol (odds ratio [OR], 1.013; 95% CI, 1.000-1.025; p = 0.043) and HDL (OR, 1.071; 95% CI, 1.021-1.123; p = 0.005) levels were associated with good neurologic outcomes.

Conclusions: The levels of total cholesterol and HDL after ROSC were associated with good neurologic outcomes in patients with OHCA, without considering the effect of other lipid profiles simultaneously.

Keywords: Cholesterol; HDL; Heart arrest; Lipid profile; Prognosis.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Cholesterol, HDL / blood*
  • Cholesterol, LDL / blood*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Out-of-Hospital Cardiac Arrest / blood*
  • Out-of-Hospital Cardiac Arrest / therapy
  • Retrospective Studies
  • Time Factors
  • Triglycerides / blood*

Substances

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides