Noninvasive Imaging to Assess Atherosclerotic Plaque Composition and Disease Activity: Coronary and Carotid Applications

JACC Cardiovasc Imaging. 2020 Apr;13(4):1055-1068. doi: 10.1016/j.jcmg.2019.03.033. Epub 2019 Aug 14.

Abstract

Cardiovascular disease is one of the leading causes of mortality and morbidity worldwide. Atherosclerosis imaging has traditionally focused on detection of obstructive luminal stenoses or measurements of plaque burden. However, with advances in imaging technology it has now become possible to noninvasively interrogate plaque composition and disease activity, thereby differentiating stable from unstable patterns of disease and potentially improving risk stratification. This manuscript reviews multimodality imaging in this field, focusing on carotid and coronary atherosclerosis and how these novel techniques have the potential to complement current imaging assessments and improve clinical decision making.

Keywords: atherosclerosis; plaque burden; positron emission tomography; vulnerable plaque.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carotid Arteries / diagnostic imaging*
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Vessels / diagnostic imaging*
  • Humans
  • Multimodal Imaging*
  • Plaque, Atherosclerotic*
  • Predictive Value of Tests
  • Rupture, Spontaneous