Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication

EuroIntervention. 2020 Jun 12;16(2):e141-e146. doi: 10.4244/EIJ-D-18-01190.

Abstract

Aims: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries.

Methods and results: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314).

Conclusions: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.

Publication types

  • Comparative Study

MeSH terms

  • Absorbable Implants*
  • Animals
  • Coronary Angiography*
  • Coronary Vessels / diagnostic imaging*
  • Coronary Vessels / drug effects
  • Drug-Eluting Stents*
  • Hemodynamics
  • Percutaneous Coronary Intervention*
  • Prosthesis Design
  • Swine
  • Tomography, Optical Coherence*
  • Treatment Outcome