Heart Failure Site-Based Research in the United States: Results of the Heart Failure Society of America Research Network Survey

JACC Heart Fail. 2019 May;7(5):431-438. doi: 10.1016/j.jchf.2019.02.008. Epub 2019 Apr 10.

Abstract

Objectives: This study sought to determine clinician and scientist involvement in heart failure (HF) clinical research and to describe the challenges of conducting clinical trials in the United States.

Background: Improvements in the current capability, potential, and deficiencies of the HF clinical research infrastructure in the United States are needed in order to enhance efficiency and impact.

Methods: The Heart Failure Society of America (HFSA) distributed an electronic survey regarding HF clinical trial activity for the purpose of understanding the barriers that exist to conducting high-quality HF clinical research.

Results: Overall, 1,794 HFSA members were queried, and 434 members (24%) completed surveys, whereas a total of 7,589 individuals with interest in HF were queried, and 615 completed surveys. Of the respondents, 410 (67%) were actively engaged in HF research and 120 (20%) were interested in research. Most respondents, 270, were physicians (44%); 311 of the total (76% of the total and 80% of physicians) practiced in academic institutions; 333 respondents (81%) had served as principal investigators and 73 (18%) as site coordinators. Respondents active in clinical research usually participated in 1 to 5 trials and enrolled 1 to 20 patients annually. Institutional review board (IRB) approval typically required 3 months, and contract completion required 3 to 6 months per site. The greatest barriers to research were insufficient site budgets, delay in contracting, inability to find participants meeting trial entry criteria, and unavailability of qualified study coordinators.

Conclusions: Many U.S. clinical research sites are constrained by budgetary, staffing, and contractual issues. The HFSA Research Network seeks to unify interested sites and deconstruct barriers to permit high-value HF research.

Keywords: clinical trials; heart failure clinical research; research network; site-based research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Academic Medical Centers
  • Biomedical Research*
  • Clinical Trials as Topic
  • Contracts
  • Cross-Sectional Studies
  • Ethics Committees, Research*
  • Heart Failure*
  • Humans
  • Nurse Practitioners
  • Nurses
  • Patient Selection*
  • Physicians
  • Research Personnel / supply & distribution*
  • Research Support as Topic*
  • Societies, Medical
  • Surveys and Questionnaires
  • Time Factors
  • United States