Patent Foramen Ovale: Story Closed?

J Stroke. 2019 Jan;21(1):23-30. doi: 10.5853/jos.2018.03097. Epub 2019 Jan 31.

Abstract

The optimal treatment strategy for secondary prevention in patients with cryptogenic stroke and patent foramen ovale (PFO) has been a matter of controversy for decades. After three randomized trials failed to show a benefit of closure with an excess of complications in the interventional arm, two large recent trials suggest a benefit with regard of preventing further ischemic strokes. With this discrepancy in results it is important to discuss recent trials in detail and evolve an informed clinical approach for daily practice.

Keywords: Foramen ovale, patent; Intracranial embolism; Stroke.