JACC CV Health Promotion Series
JACC Focus Seminar
Reprint of: Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series

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Abstract

The primary objective of this study was to analyze the most up-to-date evidence regarding whether and how blood sugar regulation influences cardiovascular health promotion and disease prevention by carrying out an umbrella review. Three separate, systematic literature searches identified 2,343 papers in total. Overall, 44 studies were included for data extraction and analysis. The included systematic reviews and meta-analyses published between January 1, 2016, and December 31, 2017, were of good to very good quality (median Overview Quality Assessment Questionnaire score = 17). Identified evidence suggests that cardiovascular disease (CVD) prevention services should consider regulation of blood glucose as a key target for intervention. Furthermore, the recommendations for effective intervention and service development/training described here for prevention of CVD should be adopted into evidence-based practice guidelines. Multidisciplinary teams should be formed to deliver multicomponent interventions in community-based settings. There may be substantial opportunities for integrating CVD and diabetes prevention services.

Key Words

blood glucose
diabetes mellitus
diet
exercise
health behavior
umbrella review
weight loss

Abbreviations and Acronyms

BP
blood pressure
CI
confidence interval
CV
cardiovascular
CVD
cardiovascular disease
DBP
diastolic blood pressure
DM
diabetes mellitus
DPP
dipeptidyl peptidase
GLP
glucagon-like peptide
GLP-1 RA
glucagon-like peptide-1 receptor agonist
HbA1c
glycosylated hemoglobin
IQR
interquartile range
MI
myocardial infarction
OQAQ
Overview Quality Assessment Questionnaire
RCT
randomized controlled trial
SBP
systolic blood pressure
SGLT2
sodium-glucose cotransporter 2
T2DM
type 2 diabetes mellitus

Cited by (0)

This article is a reprint of a previously published articles. For citation purposes, please use the original publication details: J Am Coll Cardiol 2018;72:1829-44. DOI of the original item: https://doi.org/10.1016/j.jacc.2018.07.081.

Listen to this manuscript's audio summary by JACC Editor-in-Chief Dr. Valentin Fuster.

Dr. Schwarz, Timpel, Harst, Almedawar, and Morawietz contributed equally to this work. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.