Meta-Analysis of Relation of Epicardial Adipose Tissue Volume to Left Atrial Dilation and to Left Ventricular Hypertrophy and Functions
Section snippets
Methods
We conducted the present study according to the protocols specified in the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. The study protocol was registered in PROSPERO (ID: CRD42017080849). We searched MEDLINE, Scopus, and Web of Science for publications reporting association measures between EAT and parameters of cardiac structure and function using the following expression: ([“Epicardial adipose tissue” OR “Epicardial fat” OR “Pericardial adipose tissue” OR
Results
Systematic review flowchart is depicted in Figure 1. A total of 19 reports matched our search criteria.9,11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 In them, 17 studies reported the association with total EAT volume9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,24, 25, 26 and 6 studies investigated the association with periatrial EAT.9, 13,20, 21, 22, 23 The former studies included 8,838 subjects, in which cardiac morphology and function were assessed by transthoracic echocardiography
Discussion
In this review, we pooled adjusted association measures of the volume of EAT by CT and cardiac structure and function. We observed a small, but BMI-independent, effect of EAT on LA dilation, LV hypertrophy, and LV diastolic dysfunction; no associations were found between EAT and systolic function.
Obesity may worsen myocardial remodeling by several mechanisms namely, activation of the renin-angiotensin system and autonomic nervous system, which altogether increase peripheral arterial resistance
Disclosures
The authors have declared no competing interests.
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2021, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :In the past decade, epicardial fat was recognized as a cardiometabolic active tissue. Its confirmed association with coronary heart disease [37,38], AF and diastolic HF had also triggered the interest in exploring its relationship with other cardiovascular and cardiometabolic diseases [4,39], such as diabetes mellitus (DM) and hypertension [40–42]. Meta-analysis by Li et al. concluded that DM patients were presented with higher epicardial fat value regardless of DM subtype [43].
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Funding: Mancio J is supported by the Fundação Portuguesa para a Ciência e Tecnologia (SFRH/BD/104369/2014) and by the Sociedade Portuguesa de Cardiologia (“Bolsa de investigação João Porto”). This report is a result of the project DOCnet (NORTE-01-0145-FEDER-000003) supported by the Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).
PROSPERO Registration: This study protocol was registered with PROSPERO (ID: CRD42017080849) Porto (Portugal).
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JM and DA contributed equally to this work and are joint first authors.