Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury

J Cereb Blood Flow Metab. 2019 Oct;39(10):2035-2047. doi: 10.1177/0271678X18777928. Epub 2018 May 18.

Abstract

There is a need for a method of real-time assessment of brain metabolism during neonatal hypoxic-ischaemic encephalopathy (HIE). We have used broadband near-infrared spectroscopy (NIRS) to monitor cerebral oxygenation and metabolic changes in 50 neonates with HIE undergoing therapeutic hypothermia treatment. In 24 neonates, 54 episodes of spontaneous decreases in peripheral oxygen saturation (desaturations) were recorded between 6 and 81 h after birth. We observed differences in the cerebral metabolic responses to these episodes that were related to the predicted outcome of the injury, as determined by subsequent magnetic resonance spectroscopy derived lactate/N-acetyl-aspartate. We demonstrated that a strong relationship between cerebral metabolism (broadband NIRS-measured cytochrome-c-oxidase (CCO)) and cerebral oxygenation was associated with unfavourable outcome; this is likely to be due to a lower cerebral metabolic rate and mitochondrial dysfunction in severe encephalopathy. Specifically, a decrease in the brain tissue oxidation state of CCO greater than 0.06 µM per 1 µM brain haemoglobin oxygenation drop was able to predict the outcome with 64% sensitivity and 79% specificity (receiver operating characteristic area under the curve = 0.73). With further work on the implementation of this methodology, broadband NIRS has the potential to provide an early, cotside, non-invasive, clinically relevant metabolic marker of perinatal hypoxic-ischaemic injury.

Keywords: Cerebral haemodynamics; metabolism; mitochondria; near-infrared spectroscopy; perinatal hypoxia.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / blood supply
  • Brain / metabolism
  • Brain Injuries / complications
  • Brain Injuries / metabolism*
  • Brain Injuries / therapy*
  • Cerebrovascular Circulation
  • Female
  • Humans
  • Hypothermia, Induced* / methods
  • Hypoxia / complications
  • Hypoxia / metabolism
  • Hypoxia / therapy
  • Infant, Newborn
  • Male
  • Mitochondria / metabolism*
  • Oxygen / metabolism*
  • Prospective Studies
  • Treatment Outcome

Substances

  • Oxygen