Valvular Heart DiseaseImpact of Renal Dysfunction on Results of Transcatheter Aortic Valve Replacement Outcomes in a Large Multicenter Cohort
Section snippets
Methods
A total of 1,204 consecutive patients with severe symptomatic AS who underwent TAVR from 2006 to 2015 with and without CKD were enrolled from 10 centers in Europe (Ferrarotto Hospital, Catania, Italy; Inselspital University Hospital, Bern, Switzerland; Institute Cardiovasculaire Paris Sud, Massy, France; Galway University Hospital, Galway Ireland; CHRU, Lille, France; University Hospital, Antwerp, Belgium; Bonn University Hospital, Bonn, Germany), Japan (Keio University Hospital, Keio), and
Results
Of the 1,204 patients, 288 were included in group I (eGFR >60 ml/min), 458 in group II (eGFR 31 to 60 ml/min), 452 in group III (eGFR ≤30 ml/min), and 66 in group IV (dialysis). Baseline characteristics of the study population according to CKD severity are listed in Table 1. Mean age increased with decreasing eGFR in patients who did not undergo dialysis, whereas patients in the dialysis group were the youngest (p <0.001). Mean STS score increased with decreasing eGFR (p <0.001). Baseline
Discussion
In this large multicenter analysis of patients who underwent TAVR for the treatment of severe symptomatic AS, renal dysfunction was associated with poor clinical outcomes. All-cause and cardiovascular mortality rates during the follow-up period increased with decreasing renal function. Importantly, a eGFR ≤30 ml/min was identified as an independent predictor for all-cause and cardiovascular mortality.
There is a broad agreement that TAVR outcomes are negatively influenced by advanced and
Disclosures
The authors have no conflicts of interest to disclose.
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Cited by (33)
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Drs Codner and Levi contributed equally to this article.
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