Rationale and design of the Randomized Evaluation of patients with Stable angina Comparing Utilization of noninvasive Examinations (RESCUE) trial

Arthur E Stillman; Constantine Gatsonis; João A C Lima; William C Black; Jean Cormack; Ilana Gareen; Udo Hoffmann; Tao Liu; Kreton Mavromatis; Mitchell D Schnall; James E Udelson; Pamela K Woodard

doi:10.1016/j.ahj.2016.06.003

Rationale and design of the Randomized Evaluation of patients with Stable angina Comparing Utilization of noninvasive Examinations (RESCUE) trial

Am Heart J. 2016 Sep:179:19-28. doi: 10.1016/j.ahj.2016.06.003. Epub 2016 Jun 17.

Authors

Affiliations

¹ Department of Radiology and Imaging Sciences, Emory University, 1365 Clifton Rd NE Atlanta, GA 30322; Division of Cardiology, Emory University, Atlanta GA. Electronic address: aestill@emory.edu.
² Center for Statistical Sciences, Brown University, Providence RI; Department of Biostatistics, Brown University School of Public Health, Providence RI.
³ Departments of Medicine and Radiology, Johns Hopkins University, Baltimore MD.
⁴ Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon NH.
⁵ Center for Statistical Sciences, Brown University, Providence RI.
⁶ Center for Statistical Sciences, Brown University, Providence RI; Department of Epidemiology, Brown University School of Public Health.
⁷ Department of Radiology, Massachusetts General Hospital, Boston MA.
⁸ Division of Cardiology, Emory University, Atlanta GA.
⁹ Department of Radiology, University of Pennsylvania, Philadelphia PA.
¹⁰ Division of Cardiology, Tufts-New England Medical Center, Boston MA.
¹¹ Department of Radiology, Mallinckrodt Institute of Radiology, Washington University, St. Louis MO.

Abstract

RESCUE is a phase III, randomized, controlled, multicenter, comparative efficacy study, designed to compare two diagnostic imaging/treatment paradigms that use coronary computed tomography angiography (CCTA) or single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) for assisting in the diagnosis of ischemic heart disease in patients with stable angina symptoms, and guiding subsequent treatment. The study is based on the hypothesis that CCTA as a diagnostic tool is associated with no increase in cardiac risk, decreased cost, and reduced radiation exposure compared with SPECT MPI. The RESCUE trial was funded by the Agency for Healthcare Research and Quality (AHRQ) and the American College of Radiology Imaging Network (ACRIN) Fund for Imaging Innovation, began in 2011, and completed in 2014.

Publication types

Clinical Trial, Phase III
Comparative Study
Multicenter Study
Randomized Controlled Trial

MeSH terms

Adrenergic beta-Antagonists / therapeutic use
Adult
Aged
Aged, 80 and over
Angina, Stable / diagnostic imaging*
Angina, Stable / therapy
Angiotensin Receptor Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antihypertensive Agents / therapeutic use
Computed Tomography Angiography*
Coronary Angiography*
Diet Therapy
Exercise
Female
Heart Diseases / mortality
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Male
Middle Aged
Myocardial Infarction / epidemiology
Myocardial Ischemia / diagnostic imaging*
Myocardial Ischemia / therapy
Myocardial Perfusion Imaging*
Myocardial Revascularization / statistics & numerical data
Platelet Aggregation Inhibitors / therapeutic use
Smoking Cessation
Time Factors
Tomography, Emission-Computed, Single-Photon*
Vasodilator Agents / therapeutic use

Substances

Adrenergic beta-Antagonists
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Platelet Aggregation Inhibitors
Vasodilator Agents

Grants and funding

R01 HS019403/HS/AHRQ HHS/United States